In 1946, Rev. Maurice Woulfe, associate pastor of Our Lady Help of Christians, recommended to Bishop O’Hara to purchase the property at Cleveland Drive, Cheektowaga, and establish a new church for the growing Catholic population. Once approved, Rev. John Henesey was appointed the first pastor of the new parish in this rapidly growing suburb of Buffalo, fulfilling Fr. Henesey's dream of having a parish named after his devotion to the Infant Jesus. The first Mass was said in an army tent with a temporary altar and had 150 people in attendance. These outdoor Masses continued for 8 weeks until a permanent structure was built. Throughout those 8 weeks of outdoor Masses, the weather remained perfect!

Fr. Henesey began the process of purchasing building materials for both a church and a school. The materials were secured through military surplus buildings in Niagara Falls. The sisters of St. Francis from Williamsville soon followed to staff a temporary school building for 44 children. The first principal was Sr. Mary Regina.

The new school was constructed in 1950. Within 5 years, enrollment at Infant of Prague's school was over 900 children. Ground was broken for the new, larger, one thousand seat church on the feast of Christ the King in 1959. It was blessed and dedicated by Bishop Leo Smith in 1962. The original Infant on the dome was carved in Italy.

The new parish center and rectory was constructed in 1990. The parish was merged with the faith community of Mother of Divine Grace in 2009, where the existing Chapel was renamed and redecorated to honor Mother of Divine Grace and it's parishioners.

Infant of Prague is celebrating 80 years of serving as a spiritual home for the people of God in 2026!